Flu Vaccines: Technology Developments and Effects

Flu Vaccines: Technology Developments and Effects Flu, also known as Influenza, is a contagious viral disease that affects the respiratory system. It is caused by influenza viruses. It is highly infectious unpredictable disease that spreads though secretions of nose and lungs. Flu causes mild to severe illness and sometimes even leads to death. According to U.S. CDC, in an average year, 5 to 20 percent of the U.S. population gets the flu, more than 200,000 people are hospitalized with seasonal flu-related complications and about 36,000 people die from flu-related causes.  [1]   Flu vaccination is one of the best ways to protect the community from the seasonal and pandemic flu effects. Pandemic flu is different from seasonal flu,  [2]  it is a global disease outbreak that usually occurs when a flu strain new to humans emerges and causes widespread illness. The pandemic flu is very dangerous because of newly originated strain to which humans have little pre-existing immunity and vaccines would probably not be available immediately in early stages of pandemics.2 The pandemic outbreaks have potential impact on society causing high levels of illness, death, economic loss and social disruption. Recently in 2009 a novel H1N1 virus emerged which became pandemic. It is estimated that in U.S., approximately 43-89 million persons became ill because of this pandemic H1N1. It also resulted in deaths among children, adults, pregnant and post-partum women. On the other hand seasonal flu form occurs seasonally, usually in winter. Seasonal flu causes significant illness and in some cases death. Annual vaccination: Flu vaccination is most effective way to control and prevent influenza virus infections and severe complications. It is especially important for younger children and people who are at high risk of catching infections. Flu vaccines are available as Flu shot of trivalent inactivated or killed virus (TIV) or Live Attenuated Influenza Vaccine (LAIV) as nasal spray. However, it is impossible to prevent influenza by one time vaccination because Influenza viruses undergo changes from year to year and develop resistance making previously available vaccines ineffective. Therefore scientists make different flu vaccine every year. In addition the immunity developed from having the flu caused by one strain does not always offer protection against new strain. Immunity also declines over time after previous years vaccination and at a point it may be too low to provide protection after year. Hence to combat with changing influenza viruses, vaccination is done every year. Getting seasonal flu vaccin ation offers protection that lasts throughout the year preventing infection and its complications. Vaccine recommendations: The World Health Organization organizes meetings twice a year and recommends inclusion of specific virus strains in Influenza vaccine based on results of surveillance, laboratory and clinical studies, and the availability of vaccine virus strains. Then individual countries make their own decision about inclusion of virus strains in vaccines licensed in their country. In U.S., each year, a panel of experts from agencies such as the FDA and the CDCs Advisory committee on Immunizations Practices (ACIP) studies the available data and decides which three strains of influenza viruses will most likely be active during the next flu season. The selection of vaccine strains for inclusion in seasonal flu vaccine is based on circulating virus strains, how they are spreading, and how well current vaccine strain protects against newly identified strains.  [3]  The ACIP makes written recommendations for administration of vaccines to children and adults. These recommendations include age for administration, doses, dosing interval, precautions and contraindications.  [4]  The seasonal flu vaccine for 2010-2011 offers protection against H3N2 virus, an influenza B virus and pandemic H1N1 virus that emerged in 2009. Vaccine Shortage Issue: There are many issues related to flu vaccines. Among many vaccine shortage is the most noticed every year. A close examination reveals that the shortage for vaccine is not one cause but several. Some of them include high risk of contamination in vaccine production, unpredictable consumer demand, and low profits along with lack of liability protection from costly lawsuits made many manufacturers out of flu vaccine business.  [5]   Most of the companies stopped production of flu vaccine because the demand varies from year to year, as it is always unpredictable and once flu season passes away the remaining stock is useless because a new vaccine is required to deal with changing strains of virus  [6]. According to 2003 report by Institute of Medicine, a unit of National Academy of Sciences, the companies producing vaccines dropped from 30 to 5 in year 2004.6 The companies producing injectable influenza vaccine dropped to two (Chiron Aventis Pasteur) in year 2005.5 Production of flu virus vaccine is very complicated and expensive, but the government keeps price of flu vaccine low. Among the two firms Chiron was forced to shut down its UK plant because of quality control reasons. This resulted in shortage. Another problem is that each year, the U.S. Food and Drug Administrations Vaccines and Related Biological Products Advisory Committee meets in spring identifies the flu virus strains to be protected by flu vac cine manufactured for that fall-winter flu season.5 This time gap between committees decision and following flu season allows manufactures to make vaccines but the flu strains can undergo changes by the time vaccines are manufactured for flu season. Thus it is difficult to determine for what strains of flu virus vaccine should be made which may end up with vaccine shortage for specific flu season. In 2003 committee voted to include the Panama flu virus in vaccine for the 2003-04 flu seasons, excluding Fujian flu mutant virus, a more virulent but less prevalent at that time. But the winters flu outbreak consisted almost entirely of the Fujian strain. CDC without noticing it recommended widespread vaccination which did not protect the public against the prevalent flu strain. The CDC later admitted the vaccine had no or low effectiveness against ILI (influenza-like illness). Latest development in flu vaccine research: The outbreak of pandemic flu has motivated increase in flu research The recent advancement in field of flu vaccine research is development of Universal flu vaccines. Scientist Dr. Sarah Gilbert and team at Oxford Jenner Institute developed universal flu vaccine that target proteins inside flu that are common across all strains and tested on humans infected with flu  [7]. Gilbert used 11 healthy volunteers for her study and vaccinated and then infected them along with 11 non-vaccinated volunteers. Upon careful monitoring there has been dramatic increase in T-cell count in vaccinated subjects which play important role in producing immune response, protecting against viral infections. Researchers of University of Adelaide, Dr. Darren Miller and his colleagues, have trialled a universal synthetic flu vaccine in mice which is another step closer to development of a universal flu vaccine. It is derived synthetically which does not require annual reformulation which would be advantageous to control and prevent flu. Dr. Miller used specific peptides derived from noses of mice to trigger an immune response to a tiny region of flu virus that is present in all influenza A and B viruses, which effectively neutralizes the virus.  [8]   The studies have shown that test vaccine provided mice with 100% protection against a laboratory strain of H3N2 and 20% protection against a highly pathogenic bird flu virus.8 This positive response provides scope for further laboratory and clinical testing. Economics of Flu vaccination: Economic studies indicate that flu vaccination reduces healthcare, societal, and individual costs and also productive losses associated with influenza illness.  [9]  A study of a larger population comparing persons aged 5064 years with those aged à ¢Ã¢â‚¬ °Ã‚ ¥65 years estimated the cost-effectiveness of influenza vaccination to be $28,000 per QALY saved (in 2000 dollars) in persons aged 5064 years compared with $980 per QALY saved among persons aged à ¢Ã¢â‚¬ °Ã‚ ¥65 years (393).Two studies in the United States indicated that vaccination can reduce both direct medical costs and indirect costs from work absenteeism and reduced productivity (79,394). Latest flu pandemics and their effect on the Regulatory world: The pandemic flu is unpredictable, spreads rapidly world wide affecting large proportions of the human population. There have been three influenza pandemics of which the recent one was the 2009 flu pandemic. This occurred first in Mexico, March 2009 caused by pandemic H1N1/09 virus also referred to as swine flu. It is subtype of Influenza A virus. On 10th of August 2010, the Director General of WHO announced that H1N1 pandemic virus has moved into post-pandemic period.  [10]  CDC estimated that nearly a 1 million cases of 2009 H1N1 pandemic flu had occurred in United States. The pandemic H1N1 flu cases doubled in many countries from mid-June 2009 to early July 2009. According to WHO statistics, 18,000 deaths were reported because of H1N1. This outbreak resulted in extraordinary illness throughout the world with increased demand for vaccination against the swine flu virus in a short time. The pandemics put intense burden on the regulatory authorities as vaccines have to be made available globally to meet the increased demands. Regulatory agencies adopted procedures for accelerated approval of vaccines against swine flu. In U.S., FDA expanded its capacity to expedite development, evaluation and licensing of additional flu vaccines and manufacturing facilities to meet pandemic preparedness needs  [11]. CBER has issued guidelines encouraging vaccine manufacturers to explore cell-culture and recombinant techniques, and to incorporate biological integrators, such as immune response, into their product-development designs.  [12]  The outbreak of pandemic flu also has increased collaboration among foreign regulatory agencies to share vaccine safety information and experiences and mount a coordinated response to the emer gency. Beta Lactam Antibiotics: Examples and Uses Beta Lactam Antibiotics: Examples and Uses The beta-lactam antibiotics for their extensive scale of actions are preferred most among antimicrobial factors. The penicillins and cephalosporins are the two categories of this ÃŽ ² lactam antibodies that are extraordinarily less toxic to organisms.(1) At present ,the ÃŽ ²-lactam groups of antibiotics are the highest frequently used universal antibiotics .(2) Cellular membrane of most bacteria enclosed by a cell wall but an extra outermost layer seen on some of them. The periplasmic space in gram negative bacteria is the cavity in the middle of the cell membrane and the cell wall. Periplasm instead of a clearly defined periplasmic space is retained by most gram positive bacteria .(3) But peptidoglycan is the greatest significant element of the cell wall that linked as a new cell by way of the metabolic absorption in periplasm is a polymer made of N-acetyl muramic acid alternating with N-acetyl glucosamine.Arises of the bacterial cell that is actually a process of peptidoglycan synthesis where accumulation of 5 amino acids to N-acetyl muramic acid is one of the leading phases. A precursor of peptidoglycan that conducted by a cell wall acceptor crossway the cell membrane in the periplasm and developed by linking N-acetyl glucosamine to the N-acetyl muramic acid . Generous crosslinking occurs for two key enzymes (trans peptidase and D-alanyl carboxypeptidase) and for the capacity to bind penicillins and cephalosporins, they are recognized as the penicillin binding proteins. B4 Development of cell wall by cross linking of a number of films of peptidoglycan grounds numerous layers and a much denser cell wall in gram positive bacteria than gram negative bacteria. Beta-lactam ring attach enzymes to cross-link peptidoglycans, that is a chemical structure which is available in the beta-lactam antibiotics consist of all penicillins and cephalosporins. Synthesis of bacterial cell wall is prevented by the affect of beta-lactam when transpeptidase and D-alanyl carboxypeptidase enzymes are attaching there by means of cross-linking and cause deterioration of bacterial cell wall.b5 As a bactericidal agents the antibiotic-penicillin binding protein complex of beta-lactam antibiotics excites autolysin discharge that have the capability of digest cell wall that left after bursting a cell. Generally, excessive inner osmotic pressure possessed by gram positive bacteria and in a low osmotic pressure enclosed atmosphere , cells those are lack of a usual and rigid cell wall are burst out.b6 There are many different types of methods of that bacteria became reistance to beta-lactam antibiotics. Transformation is one of the most important mechanisms among them and in the mean time of this process transfer of chromosomal genes between bacterium happens. Due to the death of a a resistance gene in a bacterium releasing of naked DNA in surrounding environment happens. a process known as homologous transformation and by this method the resistance gene in the host bacteria transferred from the naked DNA to the chromosome. the segment of the host DNA have been remodelled by resistance genes results altered penicillin binding proteins production by coding for cross-linking enzymes. But still cross linking of the peptidoglycan layers of the cell wall happens due to these altered penicillin binding proteins and reduces affinity for beta-lactam antibiotics and the bacterium became resistance. In penicillin-resistant S. pneumonia, this process caused the acquirement of genes from othe r naturally arising penicillin-resistant Streptococcus species. Bacteria grow into resistant to beta-lactam antibiotics by one more significant system is by the construction of enzymes capable of deactivating or altering the drug formerly it has a chance to apply its outcome on the bacteria.   peni The first human gammaretrovirus that is Xenotropic murine leukemia virus-related virus (XMRV) and responsible for chronic fatigue syndrome and prostate cancer (PC) have been revealed in recent times. Gammaretroviruses family is famous for their capability to activate cancer in the infested hosts. Analyzing study showed that vaccine-induced XMRV Env -specific binding and neutralizing antibodies (NAb) titers had limited span but highly changeable. in antibody levels, the different incidence stated for XMRV in a number of prostate cancer and chronic fatigue syndrome cohorts can be explained by the reasonably fast diminution . (2) Monoclonal antibodies (mAbs) have exceptional therapeutic applications in ophthalmology and can be used therapeutically by binding to molecular objects with high specificity. Tumour necrosis factor (TNF), epithelial growth factor receptor, vascular endothelial growth factor (VEGF) receptor, basic fibroblast growth factor receptor, platelet-derived growth factor, and cluster of differentiation antigens repressed by a number of single-agent therapies. Existing and future mAbs in contrast to different cytokines were evaluated for ocular disease treatment and two anti-VEGF mAbs( bevacizumab and ranibizumab), and three anti-TNF agents (infliximab, etanercept, and adalimumab), instruct ocular neovascularization and intraocular inflammation. Other mAbs showed positive results for ocular lymphoma or ocular inflammation but Ranibizumab is the only FDA-approved therapy. Intravenous application of mAbs has established satisfactory toxicity profiles, while intraocular injection may decrease the chances of systemic complications . To develop the excellence and extent of responses is the challenge for the future by merging biologic therapies while lessening side effects. 2i Leading causes of death in the world for coronary syndromes, stroke and other ischaemic arterial diseases . Therapy involves with medical actions correlating thrombolysis, antiplatelet drugs, and the re-opening of the coronary artery by angioplasty. In ischaemic cardiovascular diseases, platelet initiation is a acute phase . Chimeric Fab, c7E3 or abciximab is the only one recombinant antithrombotic antibody currently used in therapy and obstructs the ultimate phase of platelet aggregation. Subendothelium matrix activation by other platelet receptors have been recognized as prospective targets for the improvement of antithrombotic antibodies .2ii In drug development, insulin-like growth factor receptor I (IGF-IR) is becoming an attractive target. IGF-IR owed confined homology to insulin receptor and its specificity permits to distinguish between the two receptors. Recently there are some ongoing on IGF-IR and ongoing clinical trials on anti-IGF-IR monoclonal antibodies and combined treatments. 2iii

Essay examples --

The purpose of this essay is to discuss how Coca-Cola generates sustainable competitive advantage by drawing on their Resources and Capabilities within the company. I will discuss on the theoretical area, draw on secondary research and apply a ‘real world’ example. Definitions of each perspective are explained as to make a better understanding of the different types of organizations clearer. The Coca-Cola Company (Coca-Cola), founded in 1886 and based in Atlanta Georgia, is the world’s leading soft drink manufacturer who operates in more than 200 countries and produces 400 brands of non-alcoholic beverages. Coca-Cola is very successful and recognized around the world, making the company the most valuable brand internationally. Coca-Cola has been operating through eight segments, which are Africa, East, South Asia and Pacific Rim, European Union, Latin America, North America, North Asia, Eurasia and Middle East (The Coca-Cola Company, 2006). The activities of Coca-Cola spreads through all sectors of the soft drink industry. The company offers ready to drink and yet non-alcoholic beverages with carbonation as the carbonated water, flavored water, and the energy drinks. There are still beverages that includes the non-alcoholic beverages and without carbonation which includes the non-carbonated water, flavored water, teas, juice drinks, and the enhanced water. The c ompany is also offering the fountain syrup, concentrates, and syrups, which include the sweeteners and the ingredients. The company sells its finished beverage products to the distributors and the canning and bottling operators, fountain wholesaler, and the distributors. (182) Strategy is concerned with matching a firm’s resources and capabilities to the opportuniti... ...w materials into finished products. The company manufactures the syrups and sells them to partnered bottling companies that package and distributes the final product. Bottlers help sell and promote Coca-Cola brands to businesses and institutions. Also, the Outbound Logistic department excel in the duty of effective shipping processes in providing a quick delivery, reduces damages, efficient finished goods warehousing processes, shipping of goods in large lot sizes to minimize transportation costs and quality material handling equipment to increase order picking. Lastly, the marketing and sales department of Coca-Cola are greatly motivated and capable sales force, innovative tactics to promotion and advertising, selection of the utmost fitting distribution channels, accurate identification of customer segments and needs and effective pricing strategies. (171)

Of Mice And Men :: essays research papers

OF MICE AND MEN Should George have shot his friend Lennie? George probably did the right thing by shooting Lennie. How can we condemn George for sparing his friend Lennie the pain and fear of being killed by someone else? He did something society sees as wrong, but he did it for a good reason. Lennie didn’t deserve to die, but there was no other alternative. Curley wanted to kill Lennie, and since George cared for Lennie, he figured the best thing would be for him to put Lennie out of his misery.   Ã‚  Ã‚  Ã‚  Ã‚  Lennie deserved to be punished for what he did, but not to be killed. Lennie was a handicapped person with below average intelligence. He didn’t really understand what he had done, but he didn’t really fit into society either.   Ã‚  Ã‚  Ã‚  Ã‚  Curley and the others were looking for Lennie and wanted to exterminate him; they were angry and hated Lennie. If Curley would have found Lennie, he would have shot him. But that way, Lennie would have died afraid and sad. His death would have been very violent. George knew this and that’s why he did what he did. George also knew that Lennie had dug a hole for himself and could never get out. He knew they were looking for Lennie and wouldn’t stop until they killed him. He decided to do it himself in the kindest way he could. It’s like when Candy said about his dog, “I should of shot that dog myself.'; meaning it would have been kinder to the dog. Lennie was lying down, facing away from George and didn’t know he was going to be shot. He didn’t know what was going to happen, just like Candy’s dog.   Ã‚  Ã‚  Ã‚  Ã‚  Murder is never the right answer, but George didn’t really commit murder.

Politics and Global Warming Essay

Introduction   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Every day we go about our own business.   Many of us never take the time to look around and see how we are affecting our earth’s atmosphere.   Everywhere you look today you are bound to see some factory or machinery polluting our air. Just think how many times you have seen those large semi trucks or big fossil fuel factories emitting thick dark smoke into the atmosphere.   We need to come to reality and realize that all that polluting we have been doing over the last half-century is finally catching up to us. It is very easy to detect through scientific research that our earth’s climate is changing, Time magazine reports in its 2004 issue that the earth’s average temperature is increasing at a steady rate.   Yes, we all have heard the term â€Å"global warming†, however many people don’t know in depth what global warming is, or how our actions will affect our earth if we don’t respond to the issue.   If we can educate ourselves on what global warming is and how it will affect us in the near and far future, we can then begin to change our old habits of polluting and create new habits and goals to living in a much healthier and cleaner environment. The purpose of this study is to know what global warming is and what the government is doing to resolve the issue as well as what else can be done in short term and long term. Background What is global warming?   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Global Warming is an issue that concerns almost everybody worldwide: it is the primary cause for the erratic and sometimes devastating weather that is experienced around the world. Global warming is causing the rise in sea level which in turn causes the flooding of coastal areas and areas with low elevation. Global Warming and doomsday   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Will global warming spell doom for our world? Scientists believe this to be so. â€Å"Much depends on what actions we take now and in the coming years.† Meteorologist Jagadish Shukla of the University of Maryland found out that deforestation would cause rainfall in the Amazon River to decline by more than 26 percent from the current 2.5 m. to about 1.8 m. a year (Bellamy, 2000).   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   At the same time, the burning of fossil fuels, particularly coal and oil, produces sulfur dioxide and nitrogen oxides which are hazardous to the atmosphere. Findings show that a single smokestack may produce as much as 500 tons of sulfur dioxide a day. When these gases combine with oxygen and moisture, sulfuric acid and nitric acid is formed. The rain will carry the acids to the ground (acid rain) which may cause the depletion of calcium and magnesium in the soil, elements needed by plants for the formation of chlorophyll and wood, or it may cause the release of aluminum in the soil, which are poisonous and can kill the roots of trees (Carwardine, 2000). Discussion   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   During the earliest times, the life-styles of our ancestors were very simple. The air they breathed was clean. The streams were clear and free of harmful organisms. They used natural fertilizers for their agricultural crops. The surroundings were free of household throwaways.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Today, there has been a tremendous growth in science and technology. Such advances have brought about changes in terms of new products, improved equipment, and more effective methodologies. Unfortunately, this same technology which made life easier for us produced wastes which are now affecting the quality of our surrounding air, water, and land. Factories and motor vehicles send tons of pollutants into our air. Excessive air pollution poses a danger to our health and environment. It can likewise cause stunted growth and even death to our plants. Out streams are polluted by discharges from industrial plants that use chemicals.   Garbage and sink wastes are carelessly thrown in our surroundings. Synthetic fertilizers and insecticides pollute our land and farm products (Johnston, 2000).   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   At the same time, the burning of fossil fuels, particularly coal and oil, produces sulfur dioxide and nitrogen oxides which are hazardous to the atmosphere. Findings show that a single smokestack may produce as much as 500 tons of sulfur dioxide a day. When these gases combine with oxygen and moisture, sulfuric acid and nitric acid are formed (Jenner, 1999). The rain will carry the acids to the ground (acid rain) which may cause the depletion of calcium and magnesium in the soil, elements needed by plants for the formation of chlorophyll and wood, or it may cause the release of aluminum in the soil, which are poisonous and can kill the roots of trees.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Nitrous oxide or â€Å"laughing gas’ is a colorless gas with a sweet taste and odor that is used as an anesthetic in minor surgery that H2O is responsible for about 6 percent of the human contributes to greenhouse warming. Methane or â€Å"cow gas,† on the other hand, makes up about 18 percent of human contributions to greenhouse effect. Cattle, sheep, goats, and other cud-chewing animals give off methane, in burps and flatulence as they digest (Cairncross, 2002).   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   CFCs are estimated to account for 14 percent of global warming. Experts said that what is happening right now is not a matter of adding a few degrees to the average temperature of a community. A rise of this magnitude may cause life, for without the environment, creatures on earth cannot survive   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Are we all aware of the extent of the damages brought about by modernization? Have we contributed to such environmental dilemma? What have we done to minimize such danger to our lives?   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   How can we take care of our environment? We must undertake measures to preserve our resources and minimize utilization of energy before it’s too late. Our fight against pollution is an initial step toward conserving our environmental resources and energy. We must all join hands for this common goal.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Furthermore, of all issues affecting humanity, climate change is the most pervasive and truly global, posing a very real and serious threat to our environment. Climate change is the alteration of the pattern of global climate that may be due to human activity that alters the composition of the atmosphere.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   If present day emissions of greenhouse gases continue, it is estimated that the rate of increase in global mean temperatures will reach about 0.3o C per decade. This will mean a likely increase of 1o C above the present level by the year 2025, and 3o C before the end of the next century. Resolution   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   a.) Recycling and Reuse of Solid Wastes   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Solid wastes are now viewed as a potential resource which must be recovered and reused whenever possible. Since disposal forest resources are rapidly being depleted, recycling solid wastes offer a solution to both.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Consider the element phosphorus. Mined from phosphate ores, it is manufactured into fertilizers. It enters the plant tissues and we obtain it when we eat plant as vegetable. This is later excreted and joins the sewage system. The sewage system sludge can be used directly as fertilizer or soil conditioner.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Used bottles can be used over and over again. Durable plastic containers can be saved for more household uses. Tires can be recapped and used again. Old clothing materials are used as kitchen towels and bags (see Environment Matters: Industry’s Guide to the Issues, the Challenges and the Solutions, 1999).   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   If the materials cannot be used over several times, then they can be shredded and converted into a new form. Old newspapers are repulped into new paper. Broken glasses are ground and manufactured into new ones. Tires are processed to raw rubber. Protein leftovers are manufactured into animal feeds.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   b.) Conserving our Forests   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Every now and then we receive alarming news about our forests being denuded. Big logging concessionaires indiscriminately cut down trees without undertaking reforestation measures.   Without trees, the soil is loosened and rapid erosion occurs. As a result fertile topsoil is washed away, which makes growth of other forms of vegetation almost impossible. We suffer great loss of timber, wildlife, and other forest products. But the greatest danger is the occurrence of floods and global warming that cause losses of food, properties, and lives (Davidson, 1999). III. Conclusion   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   In conclusion,   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   of all issues affecting humanity, climate change is the most pervasive and truly global, posing a very real and serious threat to our environment. Climate change is the alteration of the pattern of global climate that may be due to human activity that alters the composition of the atmosphere.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   I can personally say that as a young individual, I should do something about it before it is too late and must not only depend on our government. Global warming may affect my health, if not resolved, and may take my life at risk if nature starts to avenge of what people doing.   I need to recycle and reuse my solid wastes and encourage everyone to conserve our forests by not cutting down trees without undertaking reforestation measures. In addition, burning of fuel must be avoided because it can contribute to the possibility of having a global warming.   

A Civil Action Movie Notes Essay

Dead child worth least of all Schlichtmann received a call from Anne Anderson because her son died 12 deaths from leukemia >> 8 are children Water from two city wells are contaminated by TCE Case was kicked from firm to firm It’s a hard case because it is most likely unproven Apology from â€Å"who?† >> the defendant is sure to have some professionals >> case might not be winnable Beatrice and WR Grace are the perpetrators Lawsuits begin with the complaint Will Cheeseman: lawyer for WR Grace Jerome Facher: lawyer for Beatrice Charges in the complaint: negligence, conscious pain and suffering, wrongful death Rule 11: civil law suits Facher: knock a guy down, knock him in a way that he can’t get up again â€Å"it’s about this†¦-showing pictures of little kids- Walter J. Skinner: judge MOTION: cheesman (motion to dismiss): schmn. Had no evidence >> no real investigation >> no research RULE 11 is a nonissue because it’s so old Team of geologist and engineers are needed to show if the wells are actually contaminated 6 barrels were found in the back, in a pit Solvent†¦in barrels They get dumped out back, in the ground (witness) Immune system of kids: tore down to nothing He was doing well, and he looked fine†¦it was abrupt Facher: â€Å"these people can never testify† Silicon and TCE are used to waterproof leather Silicon is poured on†¦so some of the spill will fall off of the ground 50 more barrels that city inspector didn’t find â€Å"dump it out there in the gulley† Or dump it in a ditch Pour it into a pit Dump it into the swimming pool Lawsuit: compel the others to settle Schmann wants 25 mil cash†¦and another 25 mil to establish a research foundation to establish link between chemicals and illness†¦1.5 mil annually for families for 30 years Facher claims that Schmnn wants money Geological evidence has to come first; there needs to be proof that the chemicals reach the wells first before the parents of victims can testify The questions were confusing Facher offer a 20 mil settlement for Beatrice WR Grace: Yes on Q1 Beatrice: No on all questions >> case has ended for them Grace offer 8 million >> Schmnn said that he owed the families more than that 375 K per family The companies aren’t going to clean up the place Anne was not interested in money >> she still wanted the apology >> she said that he said that they apologized with their checkbooks >> Schmnn said sorry, but Anne said it was not meaningful The families even lost more that the lawyers Dump trucks full of scraps >> kids playing with fire†¦the water went up in flames Riley told the worker to keep his mouth shut with Celtic tickets APPEAL Judge Skinner found that John Riley deliberately concealed evidence at the trial. His tanner was torn down in 1990. WR Grace was indicted by the Grand Jury for making false statements to the EPA regarding its use of TCE, acetone, and toluene. The company pleaded no contest to the acetone charge. Its Woburn plant was closed in 1990 Two companies paid 69.4 mil to clean up

Comparing”Cask of Amontillado” with “The Rats in the walls”

Compare the narrator in Poe's â€Å"Cask of Amontillado† with the narrator of â€Å"The Rats in the walls.† The style and mode of narration in any story determines how appealing a narrator becomes to his or her readers. Additionally, this has much to do with the size of readership that the narrator garners. It is worthwhile that a narrator chooses a narration style that reflects the context of the story, captivating and which gets the reader engaged and involved throughout the narration. This narration will have significant implications for the reviews as well as comments that the reader will make which translate to more or fewer people seeking to read the narrators story. The narrators in â€Å"Cask of Amontillado† and â€Å"The Rats in the Walls† share much in common about their styles, approaches, themes, and appeal to the reader although they differ substantially in some respects. â€Å"Rats in the Walls† is narrated by the last survivor of Delapore family who moves from Massachusetts to his ancestral homeland, Exham Priory in England. On multiple instances, the Delapore and his cats hear the scurrying sounds of rats behind the ways and upon investigation find a city below the subcellar of his home, which has existed for centuries and the dwellers of this underground city fed on human flesh (Lovecraft 4). The narrator in â€Å"The cask of Amontillado† is Montresor, seemingly a gentleman, but in reality, a vindictive and vengeance filled person. (Poe 1). Montresor commits a murder and is unrepentant and guiltless of his deed because he thinks that all, he did and does is right. Most of the time, Montresor is dedicated to his viewpoint which is quite cold, vengeful, brutal, and conniving. He lures his friend, Fortunato, to tunnels and tombs underground, drugs him and locks him in chains, walls him and leaves him in his position to die slowly (Poe 5). Montresor and Delapore exhibit a great deal of quality in their narration style. The tales are given from their points of view and involve crimes, and horrendous acts that get the reader aroused and somewhat scared. They keep a great deal of suspense to maintain the reader and ensure he or she follows to the end. Both narrators, however, could be questioned regarding reliability although they have various levels of any security that could be noted (Lovecraft 8).They seem to have some mental problems which make them act in ways unnatural and do things that would naturally be abominable to sane people. The fact that we have difficulties trusting the narrators question their reliability. Montresor, first, tells the story of the crime he commits fifty years later saying that he was never caught for this. Now, trusting someone telling things that happened many years ago can be difficult because in many cases, things surface a short time after they have been done. Confessions are made, or details unveiled not very long after. Walling his friend and leaving him to die with little to no remorse characteristically defines the possibility of soundness implying that he could probably not be entirely sane. This could make him be considered unreliable (Poe 8). Delapore, similarly, exhibits a high level of unreliability. He presents the story in a way that the things happen in the supernatural realm. This elicits fiction rather than reality, and the details raise many questions because few readers would be accustomed to the nature of things that unfold throughout the narration. Eating human flesh would be an act expected of animals or an unbalanced mind. There is an element of mental issue with the narrator, and this would make him unreliable (Lovecraft 10). Constant sounds of rats in the walls which are never found raise questions as to whether substantial evidence can be gathered to support the points raised in the narration. The default the tone by the narrators is one that conveys abject panic, fear, and impending doom. The mood they employ precedes or supersedes events which could reasonably justify it. Mostly, they share much in common in the narration technics, emotions, feelings, and atmospheres. However, they also differ in some ways. Delapore narrates in a setting of a family background rich in mystic scenarios. This is evident in the declaration of the finding of bones in the underground of the Priory(Lovecraft 14). Montresor narrates from a setting of being insulated which leads him to revenge (Poe 1). The motivations behind the narration are entirely different Delapore is motivated by the desire to unravel a family background which influenced him to act and behave in the way he did. Montresor is affected by the desire to resolve the dampness of his surroundings which exert pressure on him to react in a manner to repay for what has been done against him. The levels of the unreliability of the stories also differ. Delapore is somewhat fictitious in his narration and to some extent narrates from an insane person. Delapore is profoundly unreliable because the details are hard to prove in the real world from which the readers view the content of the narration (Lovecraft 16). Montresor can be termed unreliable, but the extent is not as deep because there are actual details which offer significant proof of turn of events with a human element. While for the most part, he remains unrepentant and self-justifying of the crime he commits, there is a portion where he notes his heart grew sick after he had only a brick left to seal Fortunato forever. However, he withdraws from guilty and accuses his surroundings instead. The narration is better regarding reliability as compared to Delapore. The narrative by Montresor is mostly a revenge mission which happens in the real world giving greater credit to the details (Poe 14). For Delapore, the narration based on the occult is something that questions the credibility and reliability of the details. Overall, however, there is much held in common with a few differences inherent for the narrators the nature of narration and story details. Works citedLovecraft, Howard Phillips. The Rats in the Walls. New York: WS via Publish Drive, 2018. PrintPoe, Edgar Allan.  The Cask of Amontillado. Publisher Not Identified, 2016.

An Educated Citizenry is essential to maintain Democracy Essay

In order to establish a concrete opinion on whether or not an educated citizenry is necessary to maintain a democracy, its meaning and definition should be well-understood. B y knowing the definition of educated citizenry and democracy, a link can be established as to its relationship and a learned analysis and concrete conclusion can be achieved. Democracy entails governmental processes that enable the citizens to exercise their right and power, through their duly elected representatives, to influence the enactment of policies implemented by their respective States. This means that democracy is both a right and a privilege. It is a right in the sense that the people have a say on what the government should do through the representatives they have elected. Democracy is a privilege mainly because a citizens, there is a need to exert effort to ensure that democracy is kept protected. On the other hand, an educated citizenry would entail having the educational background, intelligence and understanding that would allow them to analyze and understand concepts that pertain to policies and governmental affairs. Simply put, an educated citizen is a learned individual who knows when to assert his or her rights at the right time. Educated citizenry equates to broad-mindedness There is nothing more to say when you are dealing with a narrow-minded individual. This alone is reason enough to say that educated citizenry is very important. For democracy to work there is a need to be open-minded about things and be able to listen for the opinion of others. In order for Democracy to be maintained, and efficiently carried out, the citizenry needs representatives. It follows that the representatives would have to belong to the citizenry. In this case, the citizenry should be well-equipped to decipher who should represent them. That representation embodies the will of the citizen, and should be occupied by an intelligent, well-educated individual. As a representative of the citizens, it is but right to possess these qualities since the representative is the citizenry and vice versa. Given these reasons, it is but right to say that an educated citizenry is necessary to maintain democracy. This is attributable to the fact that with an educated citizenry, there can be established a harmonious relationship among individuals who understand and know the set rules and regulations and from there set to follow these rules, thereby creating a well organized government, essential for democracy. Educated Citizenry precedes Democracy In order for democracy to be firmly inculcated in the system of government, it is necessary that the people who intend to have a democratic government understands its concept and how it works. This inevitably means that individuals who are educated, knows the rights and obligations that need to be set and the laws that would govern the land should initiate the establishment of democracy. This translates to the fact that the framers of the law know what democracy is before they can even begin to conceptualize the idea of a democratic government. An educated citizenry becomes the foundations of a well-established democratic institution, thus its importance should not be neglected.